pentobarbital will lower the level or impact of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Pitolisant publicity is lowered by fifty% if coadministered with solid CYP3A4 inducers.
pentobarbital will decrease the extent or result of aprepitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Induction of microsomal enzymes by this drug, might shorten the 50 %-lifetime of doxycycline for as long as 2 weeks right after barbiturate therapy discontinued; keep an eye on scientific reaction to doxycycline intently if both of those drugs administered concurrently
pentobarbital will reduce the extent or impact of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
pentobarbital will reduce the level or impact of rolapitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Extended-term coadministration of potent CYP3A4 inducers with rolapitant may perhaps appreciably reduce rolapitant efficacy.
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Monitor Carefully (1)pentobarbital will lessen the extent or influence of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or impact of cortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lessen the level or result of itraconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will reduce the extent or effect of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will minimize the extent or effect of bedaquiline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Stay away from coadministration of bedaquiline with solid CYP3A4 inducers as a result of opportunity for lessened therapeutic effect
pentobarbital will lessen the level or outcome of lapatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the level or outcome of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Impact of coadministering a solid CYP3A4 inducer with fedratinib has not been researched.
pentobarbital will reduce the read more level or result of temsirolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.